Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function
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چکیده
منابع مشابه
Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function
BACKGROUND Coronary collateral arteries function as natural bypasses in the event of coronary obstruction. The degree of collateral network development significantly impacts the outcome of patients after an acute myocardial infarction (AMI). MicroRNAs (miRNAs, miRs) have arisen as biomarkers to identify heterogeneous patients, as well as new therapeutic targets in cardiovascular disease. We sou...
متن کاملCirculating microRNAs in patients with coronary artery disease.
RATIONALE MicroRNAs are small RNAs that control gene expression. Besides their cell intrinsic function, recent studies reported that microRNAs are released by cultured cells and can be detected in the blood. OBJECTIVE To address the regulation of circulating microRNAs in patients with stable coronary artery disease. METHODS AND RESULTS To determine the regulation of microRNAs, we performed ...
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Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Using a T-connection interposed in left (LCA) and right (RCA) coronary perfusion ...
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BACKGROUND Circulating microRNAs (miRNAs/miRs) are regulated in patients with coronary artery disease. The impact of transient coronary ischemia on circulating miRNA levels is unknown. We aimed to investigate circulating miRNA kinetics in response to cardiac stress in patients with or without significant coronary stenosis. METHODS AND RESULTS Eighty of 105 screened patients with stable corona...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0137035